Speech Biomarkers for Neurodegenerative Diseases

This platform invites individuals diagnosed with, or at risk of, neurodegenerative conditions to contribute short voice samples to support critical medical and scientific research.

Speech is one of the earliest and most sensitive indicators of neurological change. By collecting and analyzing voice data, researchers are able to identify subtle biomarkers associated with diseases such as Amyotrophic Lateral Sclerosis (ALS) and other motor neuron disorders. These insights play a key role in improving early detection, tracking disease progression, and developing more effective diagnostic and assistive technologies.

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About ALL-ALS

ALL-ALS is a research and data initiative designed to advance early detection and understanding of neurodegenerative diseases through speech and voice analytics.

The platform supports the development of machine-learning models that use voice as a biomarker to estimate the likelihood of Amyotrophic Lateral Sclerosis (ALS). Existing models in this field rely heavily on public datasets composed primarily of European voice samples, creating a significant representation gap for Indian populations.

ALL-ALS addresses this gap by building one of the first large-scale, clinically relevant voice datasets of Indian patients affected by ALS and other motor neuron diseases. The goal is to create a robust, diverse, and accessible resource for the Indian healthcare context.

ALL-ALS Neurodegenerative Research

Our Objectives

  • Improve the accuracy and inclusiveness of AI-based diagnostic tools
  • Enable earlier and more reliable detection of ALS
  • Support research into disease progression and speech biomarkers
  • Accelerate assistive and therapeutic technology development
  • Improve quality of life for individuals with motor neuron diseases

What is Motor Neuron Disease (MND)?

Motor Neuron Disease (MND) is a group of progressive neurological disorders affecting motor neurons — the nerve cells that control voluntary muscles. These neurons, located in the brain and spinal cord, gradually degenerate, leading to muscle weakness, atrophy, and loss of motor function.

The exact cause of MND is unknown in most cases. Around 90% of cases occur sporadically, while approximately 10% are inherited due to genetic mutations. Environmental and cellular factors may also contribute.

Early symptoms include muscle weakness, twitching, cramping, and difficulty speaking or swallowing. As the disease progresses, coordination loss, stiffness, and respiratory difficulties may develop.

Progressive neurological disorder
Affects voluntary muscle control
Symptoms worsen over time
Includes ALS and related conditions

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For research collaboration, participation queries, or general information about the ALL-ALS initiative, please reach out using the form below. Our team will respond at the earliest.

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